Successful oral tolerance induction to cow's milk in a child with allergy to extensively hydrolysed formula.

Patients' data protection. Confidentiality of data. The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study. Right to privacy and informed consent. Right to privacy and informed consent. The authors have obtained the informed consent of the patients and/or subjects mentioned in the article. The author for correspondence is in possession of this document. Protection of human subjects and animals in research. Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this investigation. et al. Anaphylaxis caused by skin prick testing with aeroallergens: case report and evaluation of the risk in Italian allergy services. fatal systemic allergic reactions induced by skin testing and immunotherapy. The risk of adverse reactions from percutaneous prick punture allergen skin testing, venipunc-ture, and body measurements: data from the second national health and nutrition examination survey 1976-1980 (NHANES II). Cow's milk allergy (CMA) is the most frequent food allergy in childhood. 1 Treatment consists of cow's milk proteins eviction , with the use of an extensively hydrolysed milk formula (eHF) being the first option in most cases, due to its good tolerance, availability and cost. 1 Few cases of IgE-mediated allergy to eHF have been reported 2-6 but oral tolerance induction (OIT) has not been previously described in children with allergy to eHF. We report the case of a boy, referred to our Immunoal-lergy department in 2010, at the age of five years, whose parents reported a severe IgE-mediated CMA diagnosed at six months of age following an episode of anaphylaxis, with gen-eralised urticaria, angio-oedema, rhinoconjunctivitis and wheeze after yoghourt ingestion, and vomiting after eating a milk-containing puree. The child began cow's milk avoidance and was started on an eHF (Aptamil ® Pepti Junior, Milupa). However, several episodes of reproducible urticaria occurred immediately after eHF introduction, for which it was stopped and a soy milk formula was prescribed. At that time the child had specific IgE (ImmunoCAP ® , Pha-dia-Thermo Fisher Scientific, Uppsala, Sweden) positive for whole cow's milk (55.2 kU/L), casein (54.8 kU/L), ␤-lactoglobulin (BLG) (16.6 kU/L) and ␣-lactalbumin (ALA) (42.9 kU/L), and negative for soy. Due to food protein-induced enterocolitis syndrome with soy milk, manifesting as recurrent diarrhoea beginning …